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Top 25 College Hoops Picks Against the Spread – Wednesday, February 26

Published 2:12 am Wednesday, February 26, 2025

There are nine games featuring a ranked team on Wednesday’s college basketball slate. Below, we provide against-the-spread picks for each contest.

Place your bets on any men’s college basketball matchup at BetMGM.

AP Top 25 Picks ATS Today

No. 16 Maryland Terrapins vs. No. 8 Michigan State Spartans

Spread Prediction

  • Computer Prediction: Maryland 76, Michigan State 72
  • Projected Favorite: Maryland by 3.7 points
  • Pick ATS: Maryland (-3.5)

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Bet on the Maryland-Michigan State spread—or any other NCAA men’s basketball matchup—with !

Key Facts

  • Time: 6:30 p.m. ET
  • Location: College Park, Maryland
  • Venue: XFINITY Center
  • TV Channel: BTN
  • Live Stream: (Regional restrictions may apply)

No. 13 Clemson Tigers vs. Notre Dame Fighting Irish

Spread Prediction

  • Computer Prediction: Clemson 79, Notre Dame 66
  • Projected Favorite: Clemson by 13.4 points
  • Pick ATS: Notre Dame (+13.5)

Bet on the Clemson-Notre Dame spread—or any other NCAA men’s basketball matchup—with !

Key Facts

  • Time: 7 p.m. ET
  • Location: Clemson, South Carolina
  • Venue: Littlejohn Coliseum
  • TV Channel: ACC Network
  • Live Stream: (Regional restrictions may apply)

No. 12 Texas A&M Aggies vs. Vanderbilt Commodores

Spread Prediction

  • Computer Prediction: Texas A&M 77, Vanderbilt 69
  • Projected Favorite: Texas A&M by 7.9 points
  • Pick ATS: Texas A&M (-7.5)

Bet on the Texas A&M-Vanderbilt spread—or any other NCAA men’s basketball matchup—with !

Key Facts

  • Time: 7 p.m. ET
  • Location: College Station, Texas
  • Venue: Reed Arena
  • TV Channel: SEC Network
  • Live Stream: (Regional restrictions may apply)

No. 1 Auburn Tigers vs. Ole Miss Rebels

Spread Prediction

  • Computer Prediction: Auburn 80, Ole Miss 69
  • Projected Favorite: Auburn by 11.1 points
  • Pick ATS: Ole Miss (+12.5)

Bet on the Auburn-Ole Miss spread—or any other NCAA men’s basketball matchup—with !

Key Facts

  • Time: 7 p.m. ET
  • Location: Auburn, Alabama
  • Venue: Neville Arena
  • TV Channel: ESPN2
  • Live Stream: (Regional restrictions may apply)

No. 18 Memphis Tigers vs. Rice Owls

Spread Prediction

  • Computer Prediction: Memphis 82, Rice 65
  • Projected Favorite: Memphis by 16.6 points
  • Pick ATS: Memphis (-13.5)

Bet on the Memphis-Rice spread—or any other NCAA men’s basketball matchup—with !

Key Facts

  • Time: 8 p.m. ET
  • Location: Memphis, Tennessee
  • Venue: FedExForum
  • TV Channel: ESPN+
  • Live Stream:

Oklahoma Sooners vs. No. 17 Kentucky Wildcats

Spread Prediction

  • Computer Prediction: Kentucky 81, Oklahoma 76
  • Projected Favorite: Kentucky by 4.8 points
  • Pick ATS: Kentucky (-3.5)

Bet on the Oklahoma-Kentucky spread—or any other NCAA men’s basketball matchup—with !

Key Facts

  • Time: 9 p.m. ET
  • Location: Norman, Oklahoma
  • Venue: Lloyd Noble Center
  • TV Channel: SEC Network
  • Live Stream: (Regional restrictions may apply)

Butler Bulldogs vs. No. 7 St. John’s Red Storm

Spread Prediction

  • Computer Prediction: St. John’s 76, Butler 70
  • Projected Favorite: St. John’s by 6.5 points
  • Pick ATS: Butler (+7.5)

Bet on the Butler-St. John’s spread—or any other NCAA men’s basketball matchup—with !

Key Facts

  • Time: 9 p.m. ET
  • Location: Indianapolis, Indiana
  • Venue: Hinkle Fieldhouse
  • TV Channel: CBS Sports Network
  • Live Stream: (Regional restrictions may apply)

No. 22 Arizona Wildcats vs. Utah Utes

Spread Prediction

  • Computer Prediction: Arizona 80, Utah 69
  • Projected Favorite: Arizona by 11.9 points
  • Pick ATS: Utah (+14.5)

Bet on the Arizona-Utah spread—or any other NCAA men’s basketball matchup—with !

Key Facts

  • Time: 9 p.m. ET
  • Location: Tucson, Arizona
  • Venue: McKale Center
  • TV Channel: ESPN+
  • Live Stream:

Arizona State Sun Devils vs. No. 25 BYU Cougars

Spread Prediction

  • Computer Prediction: BYU 75, Arizona State 73
  • Projected Favorite: BYU by 2.1 points
  • Pick ATS: Arizona State (+4.5)

Bet on the Arizona State-BYU spread—or any other NCAA men’s basketball matchup—with !

Key Facts

  • Time: 9:30 p.m. ET
  • Location: Tempe, Arizona
  • Venue: Desert Financial Arena
  • TV Channel: ESPN+
  • Live Stream:

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